Background:
Laparoscopic mesh-reinforcement of the hiatal region in the treatment of gastroesophageal reflux disease (GERD) and paraesophageal hernia (PEH) reduces the risk of recurrence. However, there are still controversies about the technique of mesh placement, shape, stucture and material. We therefore compared the tissue integration and scar formation after implantation of two different polypropylene-meshes in a rabbit model.
Methods:
A total of 20 female chinchilla rabbits were included in this study. Two different meshes (Polypropylene PP, Polyglecaprone 25 Composite PP-PG)were implanted on the abdominal diaphragm around the oesophagus. After 3 months, the implanted meshes were excised en-bloc. Histological and morpholigical analyses were carried out, including proliferation rate, apoptosis and collagen type I/III ratio.
Results:
According to values of proliferation rate of the oesophagus, implantation of the different meshes PP (9.31 +/- 3.4 %) and PP-PG (13.26 +/- 2.54 %) affected proliferation significantly (p=0.0097). Regarding the diaphragm, we also found a significant (p=0.00066) difference between PP (9.43 +/- 1.45 %) and PP-PG (18.73 +/- 5.92 %). Comparing oesophagus and diaphragm, we proved a significant difference within PP-PG-group (p=0.0195). Within the PP-group the difference reached no statistical significance (p=0.88). We found the same results regarding apoptosis. Furthermore, there is a significant (p=0.00013) difference of collagen type I/III ratio in PP-PG (12.28 +/- 0.8) compared with PP (8.44 +/- 1,63) in the case of the oesophagus. Concerning the diaphragm, we also found a significant difference (p=0.000099) between PP-PG (8.85 +/- 0.81) and PP (6.32 +/- 1.07).
Conclusion:
The histologic and morphologic characteristics after prosthetic enforcement of the hiatus in this animal model show a more distinct tissue integration using PP-PG compared with PP. Additionally, different wound healing and remodelling capability influence the mesh tissue integration in diaphragm and oesophagus.
Readership and subscriptions to The Business of Fashion have continued to grow, largely through a campaign of whispers where one person tells another person who tells another person. This is exactly how we’d like to get around. So, thanks to all of you for recommending BoF to your colleagues and friends in the fashion business.
With this continued momentum, I thought it was about time we began to deliver more features and content — but I can’t possibly create all this on my own. And so, today I am pleased to welcome our first two contributors to the Business of Fashion, Robert Cordero and W. David Marx.
You may have already been enjoying our new BoF Daily Digest. There is so much clutter, gloss and noise around the fashion business on the Internet, that we thought an edited selection of the day’s most
intelligent news and features about the fashion business would be useful for BoF readers.
As Katlin from Urple commented yesterday "I definitely can’t keep up with all the articles coming out, but this
helps narrow it down to the ones I’m interested in. Now, I just need to
make time to actually read them, but at least I know I can find them
here!" I couldn’t have said it better — this is exactly what the Daily Digest is about.
This will be the place to come everyday for only the most intelligent and informative news . The BoF Daily Digest will be published each day by 3pm London/10am New York, and will
appear in your email inbox first thing the next morning if you are an email subscriber. The Daily Digest will be edited by the talented Robert Cordero, who is also one of the key people behind JC Report. Robert is also a great business writer who will also contribute feature articles to BoF from time to time.
Some of you may remember the name W. David Marx from my trip to Japan. I felt like I had only just begun to tap the well of David’s expertise, and so he will be giving us the scoop on everything that is Japanese fashion.
Expect David’s first feature in the coming weeks. In the meantime, you can check out the fascinating article he wrote on the changing brand value A Bathing Ape (aka BAPE), the Japanese wunder-brand founded by Nigo. David is probably the world’s foremost expert on BAPE as he wrote his master’s thesis on the topic.
Welcome to both David and Robert and we hope you will enjoy our new features.
Do you have any feedback about how we can continue to improve The Business of Fashion? Don’t be shy. Tell us what you think.
